Levkin Research Group of Biofunctional Materials

125. Liquid Wells as Self-Healing, Functional Analogues to Solid Vessels

Johannes M. Scheiger, Mariia A. Kuzina, Michael Eigenbrod, Yanchen Wu, Fei Wang, Stefan Heißler, Steffen Hardt, Britta Nestler, Pavel A. Levkin

Advanced Materials, 2021, 33(2100117)

124. High-throughput screening of multifunctional nanocoatings based on combinations of polyphenols and catecholamines

Farid Behboodi-Sadabad, Shuai Li, Wenxi Lei, Yanxi Liu, Timo Sommer, Pascal Friederich, Caroline Sobek, Phillip B. Messersmith, Pavel A. Levkin

Materials Today Bio, 2021, 10(100108)

123. Fast Nanoliter‐Scale Cell Assays Using Droplet Microarray–Mass Spectrometry Imaging

Carina RamalloGuevara, Dorothea Paulssen, Anna A. Popova, Carsten Hopf, Pavel A. Levkin

Advanced Biology, 2021, 5(3)

122. Fabrication of Quasi‐2D Shape‐Tailored Microparticles using Wettability Contrast‐Based Platforms

Mafalda D. Neto, Aukha Stoppa, Miguel A. Neto, Filipe J. Oliveira, Maria C. Gomes, Aldo R. Boccaccini, Pavel A. Levkin, Mariana B. Oliveira, João F. Mano

Advanced Materials, 2021, 33(14)

121. 3D printing of inherently nanoporous polymers via polymerization-induced phase separation

Zheqin Dong, Haijun Cui, Haodong Zhang, Fei Wang, Xiang Zhan, Frederik Mayer, Britta Nestler, Martin Wegener & Pavel A. Levkin

Nature Communications, 2021, 12(247)

120. Assembly of Multi‐Spheroid Cellular Architectures by Programmable Droplet Merging

Haijun Cui, Xianxian Wang, Janine Wesslowski, Tina Tronser, Jakob Rosenbauer, Alexander Schug, Gary Davidson, Anna A. Popova, Pavel A. Levkin

Advanced Materials, 2021, 33(4)

119. A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening

Maximilian Benz, Arndt Asperger, Meike Hamester, Alexander Welle, Stefan Heissler & Pavel A. Levkin

Nature Communications, 2020, 11(5391)

118. Controlling Geometry and Flow Through Bacterial Bridges on Patterned Lubricant‐Infused Surfaces (pLIS)

Wenxi Lei, Peter Krolla, Thomas Schwartz, Pavel A. Levkin

Small, 2020, 16(52)

117. Droplet‐Microarray: Miniaturized Platform for High‐Throughput Screening of Antimicrobial Compounds

Wenxi Lei, Konstantin Demir, Joerg Overhage, Michael Grunze, Thomas Schwartz, Pavel A. Levkin

Advanced Biosystems, 2020, 4(10)

116. Cell-based high-throughput screening of cationic polymers for efficient DNA and siRNA delivery

Yihang Wu, Ling Wang, Yue Xiong, Zhou Quanming, Linxian Li, Guanyu Chen, Yulei Ping, Gary R Davidson, Pavel A Levkin, Liqian Gao, Wenbin Deng

Acta Biomaterialia, 2020, 115, 410-417

115. Regeneration of β‐Cyclodextrin Based Membrane by Photodynamic Disulfide Exchange — Steroid Hormone Removal from Water

Zheqin Dong, Matteo Tagliavini, Jason Darmadi, Vanessa Trouillet, Andrea I. Schäfer, Pavel A. Levkin

Advanced Materials Interfaces, 2020, 7 (22), 1902100

114. Miniaturized Drug Sensitivity and Resistance Test on Patient-Derived Cells Using Droplet-Microarray

Anna A. Popova, Sascha Dietrich, Wolfgang Huber, Markus Reischl, Ravindra Peravali, Pavel A. Levkin

SLAS TECHNOLOGY Translating Life Sciences Innovation, 2020, 26 (3), 274-286

113. 3D Two‐Photon Microprinting of Nanoporous Architectures

Frederik Mayer, Daniel Ryklin, Irene Wacker, Ronald Curticean, Martin Čalkovský, Andreas Niemeyer, Zheqin Dong, Pavel A. Levkin, Dagmar Gerthsen, Rasmus R. Schröder, Martin Wegener

Advanced Materials, 2020, 32(32)

112. Assembly of Materials Building Blocks into Integrated Complex Functional Systems

Joanna Aizenberg Pavel A. Levkin

Advanced Functional Materials, 2020, 30(26)

111. Thin silica‐based microsheets with controlled geometry

Marta M., Maciel Sónia G., Patrício João Borges, Pavel A. Levkin, Tiago R. Correia, João F. Mano

European Journal of Inorganic Chemistry 2020, 17, 1574-1578

110. eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

Janine Wesslowski, Pawel Kozielewicz, Xianxian Wang, Haijun Cui, Hannes Schihada, Dominique Kranz, Pradhipa Karuna M, Pavel Levkin, Julia Christina Gross, Michael Boutros, Gunnar Schulte* and Gary Davidson*

Journal of Biological Chemistry, 2020, 295 (26), 8759-8774

109. Development of new self-assembled cationic amino liposomes for efficient gene delivery

Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A. Levkin, Gary Davidson, Liqian Ga and Wenbin Deng

Biomaterials Science, 2020, 8(11)

108. Inverse Vulcanization of Styrylethyltrimethoxysilane – Coated Surfaces, Particles and Crosslinked Materials

Johannes Martin Scheiger, Pavel Levkin, Patrick Theato

Angewandte Chemie International Edition, 2020, 59(42)

107. Facilitating an International Research Experience Focused on Applied Nanotechnology and Surface Chemistry

C Wilson, M Hirtz, PA Levkin, AL Sutlief, AE Holmes

Journal of Chemical Education, 2020, 96 (11), 2441-2449

106. Miniaturized high-throughput synthesis and screening of responsive hydrogels using nanoliter compartments 

A Rosenfeld, C Oelschlaeger, R Thelen, S Heissler, PA Levkin

Materials Today Bio, 2020, 100053

105. Precision Medicine in Oncology: In Vitro Drug Sensitivityand Resistance Test (DSRT) for Selection of PersonalizedAnticancer Therapy

A.A. Popova and P.A. Levkin

Advanced Therapeutics, 2020, 1900100

104. High‐Throughput Screening of Cell Transfection Enhancers Using Miniaturized Droplet Microarrays

Yanxi Liu, Tina Tronser, Ravindra Peravali, Markus Reischl, Pavel A. Levkin

Advanced Biosystems, 2020, 4 (3), 1900257

103. Combinatorial Synthesis of a Lipidoid Library by Thiolactone Chemistry: In Vitro Screening and In Vivo Validation for siRNA Delivery

Mijanur Molla, Shraddha Chakraborty, Leonel Munoz–Sagredo, Markus Drechsler, Veronique Orian-Rousseau, Pavel A Levkin

Bioconjugate Chemistry, 2020, 31 (3), 852-860

102. Nanomolar Synthesis in Droplet Microarrays with UV-triggered On-Chip Cell Screening

M Brehm, S Heissler, S Afonin, PA Levkin

Small, 2020, 1905971

101. Hydrogels with Preprogrammable Lifetime via UV-Induced Polyemerization and Degradation

Johannes Scheiger and Pavel A Levkin

Advanced Functional Materials, 2020, 1909800

100. Solid-phase combinatorial synthesis using microarrays of microcompartments with light-induced on-chip cell screening

Alisa Rosenfeld, Marius Brehm, Alexander Welle, Vanessa Trouillet, Stefan Heissler, Maximilian Benz, Pavel A Levkin

Materials Today Bio, 2019, 100022

99. International research experience for undergraduate students

Christina Wilson, Michael Hirtz, Pavel Levkin, Andrea Holmes

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257

98.  Inherent Photodegradability of Polymethacrylate Hydrogels: Straightforward Access to Biocompatible Soft Microstructures

L. Li, J. M. Scheiger, T. Tronser, C. Long, K. Demir, C. L. Wilson, M. A. Kuzina, P. A. Levkin

Advanced Functional Materials, 2019, 1902906

97. Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening

Maximilian Benz, Mijanur R. Molla, Alexander Böser, Alisa Rosenfeld, Pavel A. Levkin

Nature Communication, 2019, 2879 

96. Facile One Step Formation and Screening of Tumor Spheroids Using Droplet-Microarray Platform

Anna A Popova, Tina Tronser, Konstantin Demir, P Haitz, Karolina Kuodyte, Vytaute Starkuviene, Piotr Wajda, Pavel A Levkin

Small, 2019, 1901299

95. Droplet sorting and manipulation on patterned two-phase slippery lubricant infused surface

D Paulssen, S Hardt, PA Levkin

ACS applied materials & interfaces, 2019

94. Design and Application of Photoresponsive Hydrogels

L Li, JM Scheiger, PA Levkin

Advanced Materials, 2019, 1807333

93. High-Throughput Combinatorial Synthesis of Stimuli-Responsive Materials

A Rosenfeld, PA Levkin

Advanced Biosystems, 2019, 1800293

92. UV-Triggered Polydopamine Secondary Modification: Fast Deposition and Removal of Metal Nanoparticles

Yi Zeng, Xin Du, Wei Hou, Xiaojiang Liu, Cun Zhu, Bingbing Gao, Liangdong Sun, Qiwei Li, Junlong Liao, Pavel A Levkin, Zhongze Gu

Advanced Functional Materials, 2019, 1901875

91. Biofilm Bridges Forming Structural Networks on Patterned Lubricant-Infused Surfaces

W Lei, J Bruchmann, JL Rüping, PA Levkin, T Schwartz

Advanced Science, 2019, 1900519

90. Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

J Li, E Ueda, D Paulssen, PA Levkin

Advanced Functional Materials, 2018, 1802317

89. Surface Functionalization and Patterning by Multifunctional Resorcinarenes

F Behboodi-Sadabad, V Trouillet, A Welle, PB Messersmith, PA Levkin

ACS applied materials & interfaces, 2018, 10, 39268-39278

88. Nanoliter deposition on star-shaped hydrophilic-superhydrophobic patterned surfaces

Bo Chang, Oskari Kivinen, Ivana Pini, Pavel A Levkin, Robin HA Ras, Quan Zhou

Soft matter, 2018, 14, 7500-7506

87. Superoleophobic Slippery Lubricant‐Infused Surfaces: Combining Two Extremes in the Same Surface

Zheqin Dong, Martin F Schumann, Matti J Hokkanen, Bo Chang, Alexander Welle, Quan Zhou, Robin HA Ras, Zhenliang Xu, Martin Wegener, Pavel A Levkin

Advanced Materials, 2018, 1803890

86. Reparable Superhydrophobic Surface with Hidden Reactivity, Its Photofunctionalization and Photopatterning

Xin Du, Min Wang, Alexander Welle, Farid Behboodi‐Sadabad, YuLi Wang, Pavel A Levkin, Zhongze Gu

Advanced Functional Materials, 2018, 1803765

85. Droplet Microarray: miniaturized platform for rapid formation and high throughput screening of embryoid bodies

T Tronser, K Demir, M Reischl, M Bastmeyer, PA Levkin

Lab on a Chip, 2018

84. Formation of Liquid-Liquid Micropatterns through Guided Liquid Displacement on Liquid-Infused Surfaces

D Paulssen, W Feng, I Pini, PA Levkin

Advanced Materials Interfaces,  2018, 1800852

83. Improved extraction repeatability and spectral reproducibility for liquid extraction surface analysis-mass spectrometry using superhydrophobic-superhydrophilic patterning 

Joris Meurs, Morgan R Alexander, Pavel A Levkin, Simon Widmaier, Josephine Bunch, David A Barrett, Dong-Hyun Kim

Analytical Chemistry 90 (10), 2018, 6001-6005

82. Bacterial cellulose promotes long-term stemness of mESC

T Tronser, A Laromaine, A Roig, PA Levkin

ACS applied materials & interfaces 2018

81. Bio-Inspired Strategy for Controlled Polymerization and Photopatterning of Plant Polyphenols

Farid Behboodi-Sadabad, Huijie Zhang, Vanessa Trouillet, Alexander Welle, Nicolas Plumeré, Pavel A Levkin

Chemistry of Materials 2018

80. Droplet Microarrays: From Surface Patterning to High‐Throughput Applications

W Feng, E Ueda, PA Levkin

Advanced Materials, 1706111 2018

79. One-Pot Parallel Synthesis of Lipid Library via Thiolactone Ring Opening and Screening for Gene Delivery

MR Molla, A Böser, A Rana, K Schwarz, PA Levkin

Bioconjugate chemistry 2018

78. Free-standing three-dimensional hollow bacterial cellulose structures with controlled geometry via patterned superhydrophobic-hydrophilic surfaces

A Laromaine, T Tronser, I Pni, S Parets, PA Levkin, A Roig

Soft Matter 2018

77. Patterned superhydrophobic surfaces to process and characterize biomaterials and 3D cell culture

AI Neto, PA Levkin, JF Mano

Materials Horizons 2018

76. Micro-patterns on nanocellulose films and paper by photo-induced thiol–yne click coupling: a facile method toward wetting with spatial resolution

J Guo, I Filpponen, LS Johansson, S Heiβler, L Li, P Levkin, OJ Rojas

Cellulose 25 (1), 367-375 2018

75. Fish-microarray: miniaturized platform for single-embryo high-throughput screenings

Anna A. Popova, Daniel Marcato, Ravindra Peravali, Ilona Wehl, Ute Schepers, and Pavel A. Levkin

Advanced Functional Materials 2017

74. Droplet Microarray Based on Patterned Superhydrophobic Surfaces Prevents Stem Cell Differentiation and Enables High-Throughput Stem Cell Screening

Tina Tronser, Anna A Popova, Mona Jaggy, Martin Bastmeyer and Pavel A Levkin

Advanced Healthcare Materials 2017, 1700622.
doi: 10.1002/adhm.201700622

73. Miniaturized platform for high-throughput screening of stem cells

Tina Tronser, Anna A Popova, and Pavel A Levkin

Current Opinion in Biotechnology
Volume 46, August 2017, Pages 141–149

72. High-Density Droplet Microarray of Individually Addressable Electrochemical Cells

Huijie Zhang, Tobias Oellers, Wenqian Feng, Tarik Abdulazim, En Ning Saw, Alfred Ludwig, Pavel A. Levkin, and Nicolas Plumeré

Anal. Chem., 2017, 89 (11), pp 5832–5839
DOI: 10.1021/acs.analchem.7b00008

 

71. UV-Triggered Polymerization, Deposition, and Patterning of Plant Phenolic Compounds

Farid Behboodi-Sadabad, Huijie Zhang, Vanessa Trouillet, Alexander Welle, Nicolas Plumeré, and Pavel A. Levkin

Advanced Functional Materials, Volume 27, Issue 22, 2017
 doi: 10.1002/adfm.201700127

 

70. Phospholipid arrays on porous polymer coatings generated by micro-contact spotting

Sylwia Sekula-Neuner, Monica de Freitas, Lea-Marie Tröster, Tobias Jochum, Pavel A Levkin, Michael Hirtz, and Harald Fuchs

Beilstein J Nanotechnol. 2017; 8: 715–722.
 doi: 10.3762/bjnano.8.75, 

 

69. Bio-inspired strategy for controlled dopamine polymerization in basic solutions

Xin Du, Linxian Li, Farid Behboodi-Sadabad, Alexander Welle, Junsheng Li, Stefan Heissler, Huijie Zhang, Nicolas Plumerée and Pavel A. Levkin

Polymer Chemistry, Issue 14, 2017

68. CD44v6-Peptide Functionalized Nanoparticles Selectively Bind to Metastatic Cancer Cells

Linxian Li, Mark Schmitt, Alexandra Matzke-Ogi, Parvesh Wadhwani, Veronique Orian-Rousseau,and Pavel A. Levkin

Adv. Sci., 2017, 4, 1600202

67. Patterned SLIPS for the Formation of Arrays of Biofilm Microclusters with Defined Geometries

Julia Bruchmann, Ivana Pini, Tejeshwar S. Gill, Thomas Schwartz, Pavel A. Levkin

66. Droplet Microarray Based on Superhydrophobic-Superhydrophilic Patterns for Single Cell Analysis

Gabriella E. Jogia, Tina Tronser, Anna A. Popova and Pavel A. Levkin

Microarrays, 2016, 5, 28

65. Evaluation of the Droplet-Microarray Platform for High-Throughput Screening of Suspension Cells

Anna A. Popova, Claire Depew, Katya Manuella, Alexander Trubitsyn, Ravindra Peravali, Markus Reischl, and Pavel A. Levkin

64. UV-Induced Disulfide Formationand Reduction for Dynamic Photopatterning

Lei Li, Wenqian Feng, Alexander Welle and Pavel A. Levkin

 

63. Facile fabrication of robust superhydrophobic surfaces: comparative investigation

Robin M. Bär, Simon Widmaier, Pavel A. Levkin

62. Collaborative Action of Surface Chemistry and Topography in the Regulation of Mesenchymal and Epithelial Markers and the Shape of Cancer Cells

Li J, Kwiatkowska B, Lu H, Voglstätter M, Ueda E, Grunze M, Sleeman J, Levkin PA, Nazarenko I

61. Superhydrophilic–Superhydrophobic Patterned Surfaces as High-Density Cell Microarrays: Optimization of Reverse Transfection

Erica Ueda, Wenqian Feng, and Pavel A. Levkin

60. Fabrication of Hydrogel Particles of Defined Shapes Using Superhydrophobic-Hydrophilic Micropatterns

 Ana I. Neto, Konstantin Demir, Anna A. Popova, Mariana B. Oliveira, João F. Mano and Pavel A. Levkin

59. Droplet-Microarray on Superhydrophobic-Superhydrophilic Patterns for High- Throughput Live Cell Screenings

A. A. Popova, K. Demir, T. G. Hartanto, E. Schmitt and P. A. Levkin

RSC Adv., 2016, 6, 38263-38276

58. Single-Step Fabrication of High-Density Microdroplet Arrays of Low-Surface-Tension Liquids

W. Feng, L. Li, X. Du, A. Welle, and P. A. Levkin

57. Single-Tailed Lipidoids Enhance the Transfection Activity of Their Double-Tailed Counterparts

Y. Wu, L. Li, Q. Chen, Y. Su, P. A. Levkin, and G. Davidson

ACS Comb. Sci., 2016, 18, 43-50 

56. Surface functionalization of conjugated microporous polymer thin films and nanomembranes using orthogonal chemistries

P. Lindemann, A. Schade, L. Monnereau, W. Feng, K. Batra, H. Gliemann, P. Levkin, S. Bräse, C. Wöll and M. Tsotsalas

J. Mater. Chem. A, 2016, 4, 6815-6818

55. Click-Chemistry Immobilized 3D-infused Microarrays in Nanoporous Polymer Substrates

M. Hirtz, W. Feng, H. Fuchs, P.A. Levkin

Adv. Mater. Interfaces, 2016, 3, 1500469

54. Dual stimuli-responsive polyamines derived from modified N-vinylpyrrolidones through CuAAC click chemistry

A. del Prado, R. Navarro, P. A. Levkin, A. Gallardo, C. Elvira and H. Reinecke

J. Polym. Sci. A, 2016, 54, 1098–1108

53. Combinatorial Approach to Nanoarchitectonics for Nonviral Delivery of Nucleic Acids

M. Molla, P.A. Levkin

Adv. Mater., 2015, 28, 1159-1175

52. Freestanding MOF Microsheets with Defined Size and Geometry Using Superhydrophobic–Superhydrophilic Arrays

M. Tsotsalas, H. Maheshwari, S. Schmitt, S. Heißler, W. Feng and P.A. Levkin

Adv. Mater. Interfaces, 2015, 3, 1500392

51. Hierarchical Micro-Nano Surface Topography Promotes Long-term Maintenance of Undifferentiated Mouse Embryonic Stem Cells

M. Jaggy, P. Zhang, A. M. Greiner, T.J. Autenrieth, V. Nadashkivska, A. N. Efremov, C. Blattner, M. Bastmeyer, P.A. Levkin

Nano Letters, 2015, 15, 7176-7154

50. Droplet-Array (DA) Sandwich Chip: A Versatile Platform for High-Throughput Cell Screening Based on Superhydrophobic–Superhydrophilic Micropatterning

Anna A. Popova, Sebastian M. Schillo, Konstantin Demir, Erica Ueda, A. Nesterov-Mueller and Pavel A. Levkin

Adv. Mat., 2015, 27, 5217-5222

49. Reversible and Rewritable Surface Functionalization and Patterning via Photodynamic Disulfide

Xin Du, Junsheng Li, Alexander Welle, Linxian Li, Wenqian Feng and Pavel A. Levkin

Adv. Mat., 2015, 27, 4997-5001

48. UV-induced tetrazole-thiol reaction for polymer conjugation and spatial control of surface

Wenqian Feng, Linxian Li, Chengwu Yang, Alexander Welle, Oliver Trapp and Pavel A. Levkin

Angewandte Chemie Int. Ed., 2015, 54, 8732–8735

47. ScreenFect A: an efficient and low toxic liposome for gene delivery to mesenchymal stem cells

Li-Ming Li, Gui-Xin Ruan, Ming-Yi HuangFu, Zhi-Lan Chen, Hui-Na Liu, Lin-Xian Li, Yu-Lan Hu, Min Han, Gary Davidson, Pavel A Levkin, Jian-Qing Gao

Int. J. Pharm., 2015, 488, 1-11

46. Reactive Superhydrophobic Surface and Its Photoinduced Disulfide-ene and Thiol-ene (Bio)functionalization

Junsheng Li, Linxian Li, Xin Du, Wenqian Feng, Alexander Welle, Oliver Trap, Michael Grunze, Michael Hirtz,  and Pavel A. Levkin

Nano Lett., 2015, 15 (1), 675-681

45. Direct three-dimensional imaging of polymer–water interfaces by nanoscale hard X-ray phase tomography

Yin Cheng, Heikki Suhonen, Lukas Helfen, Junsheng Li, Feng Xu, Michael Grunze, Pavel A. Levkin and Tilo Baumbach

Soft Matter, 2014, 10, 2982

44. UV-Triggered Dopamine Polymerization: Control of Polymerization, Surface Coating, and Photopatterning

Xin Du, Linxian Li, Junsheng Li, Chengwu Yang, Nataliya Frenkel, Alexander Welle, Stefan Heissler, Alexei Nefedov, Michael Grunze and Pavel A. Levkin

Adv. Mater., 2014, 26, 8029-8033

43. Surface Patterning via Thiol-Yne Click Chemistry: anExtremelyFast and Versatile Approach to Superhydrophilic-Superhydrophobic Micropatterns

Wenqian Feng, Linxian Li, Erica Ueda, Junsheng Li, Stefan Heißler, Alexander Welle, Oliver Trapp and Pavel A. Levkin

Advanced Materials Interfaces, 2014, 1, 1400269  

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